Thus, the clinicians should be aware of this rare disease for prompt diagnosis. An accurate diagnosis may have an impact on prognostication of tumor and understanding the biology of the tumor. Histopathological diagnosis of mucinous tubular spindle cell carcinoma of the kidney was given, and the patient responded well after the treatment. The cut section revealed a well-circumscribed tumor with yellowish-white variegated areas measuring 11 cm × 8 cm × 7 cm. She underwent left open radical nephrectomy. Computed axial tomography scan revealed a well-circumscribed mass of 11 cm involving the lower pole of the left kidney. A 61-year-old female presented with a palpable left renal lump of 12 cm in size. We report our experience with a case of mucinous tubular spindle cell carcinoma involving the kidney. MTSCC-K is a rare variant of renal cell carcinoma with female predominance and favorable prognosis. There are really no clinical symptoms that would distinguish this particular cancer from other types of breast cancers. Risk factors for developing spindle cell carcinoma include being male, smoking, alcohol consumption, and previous irradiation. Spindle cell carcinoma of the breast is a rare sub-type of breast cancer, that falls within the general category of metaplastic breast carcinoma. #Spindle cell carcinoma skinThis tumor is supposed to have good prognosis, though follow-up data are limited due to rarity of tumor. Most squamous cell skin cancers are caused by repeated and unprotected skin exposure to ultraviolet (UV) light from sunlight and tanning beds, however, spindle cell carcinomas are not caused by sun exposure. 2013 20:2345-2351.In the World Health Organization classification system, mucinous tubular and spindle cell carcinoma of the kidney (MTSCC-K) has been described as a rare pathologic subtype of renal cell cancer. Desmoplastic melanoma: is there a role for sentinel lymph node biopsy?. A diagnostic algorithm to distinguish desmoplastic from spindle cell melanoma. #Spindle cell carcinoma fullCheck out my full length video on squamous cell carcinoma &.Weissinger SE, Keil P, Silvers DN, Klaus BM, et al. Sarcomatoid SCC (Spindle Cell Squamous Cell Carcinoma): 5-Minute Pathology Pearls Desmoplastic melanoma – the step-child in the melanoma family?. Clinical approach should be nuanced based on this data.Īt SCARS Center, we attempt to simplify this information with a knowledge chart that summarizes the facts and highlights the controversies. There is a difference in recurrence rates, lymph node metastases, and mortality. These represent a spectrum of subtypes that have variable spindle cell cellularity and collagen density. Spindle cell breast cancer tends to affect post-menopausal women, but not exclusively. Spindle cell DCIS is distinguished from the streaming pattern of ordinary IDH by its solid growth pattern, lack of secondary spaces or peripheral fenestrations, uniformity of appearance and distribution of nuclei, cytological atypia in the range of low to intermediate-grade DCIS, and negative immunoreaction with CK-34E12 (HMW-CK903). Indeed, research estimates the rate to be between 0.2 and 0.5 of all breast cancers. SpCC confined solely to the nasal cavity is extremely rare, with only one case having been previously reported.2Herein we present a case of SpCC confined to the nasal cavity. In the upper aerodigestive tract, similar to conventional SCC, SpCC occurs most commonly in the larynx.1Less common primary sites include the hypopharynx, oropharynx, sinuses, and nasal cavity. The incidence rate for spindle cell breast cancer is actually very low. Spindle cell carcinoma (SpCC) is a unique and challenging variant of squamous cell carcinoma (SCC). Histopathology, presentation, surgical resection margins, and temporary closure with xenograftĭesmoplastic melanoma and spindle cell melanoma are two distinct melanoma subtypes that differ clinically and histologically. Spindle cell cancer is actually more common in the oral cavity and the larynx than in the breast. The patient was treated postoperatively with PD-1 inhibitor, pembrolizumab (Keytruda). Additional 1.2 cm margin was resected for wide clearance creating a 10 x 9 cm defect. Final pathology showed malignant melanoma-spindle cell / desmoplastic type. Spindle cell lesions can occur in head and neck skin, in the soft tissues of the scalp, orbit, and neck, and along the upper aerodigestive tract (UADT) mucosa. The tumor was resected with a 2 cm margin. Incisional biopsy showed spindle cell melanoma. A 67-year-old man with CLL presents with 3 month h/o 3 cm dense dermal growing scalp mass.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |